Soriatane and/or Equivalents
|Drug||Related Drug Names|
|Soriatane 10mg and/or Equivalents||Acitretin, Soriatane|
|Soriatane 25mg and/or Equivalents||Acitretin, Neotigason, Soriatane|
Soriatane is used to treat severe forms of psoriasis, which is associated with the formation of bubbles or large areas of reddish inflammatory skin. Its main ingredient is acitretin. Acitretin, an organic chemical compound and a synthetic analogue of retinoic acid, is used in the symptomatic treatment of severe psoriasis. It is in a group of retinoids (vitamin A derivatives). It is involved in the control of growth and maturation of healthy epidermal cells and affects certain immune reactions in the second dermis. These two mechanisms lead to the formation of the epidermal cells. New epidermal overgrowth can be prevented by the containment of horny scales and existing epidermal overgrowth can be replaced within days.
Soriatane reaches its highest plasma concentration after one to four hours of its administration. Food, especially rich in fats, contributes positively to its absorption. The average bioavailability of the drug is, on an average, about 60%, but it is highly dependent on individual factors and can range from 35% to 90%. Since it is a very lipophilic substance, it penetrates well into tissues and crosses the blood-placenta.
Soriatane is metabolized to form the cis-isomer (13-cis-Soriatane), which then undergoes several metabolic reactions. The final stage of the metabolic pathway is the disconnection of the side chain. Small amounts of the drug undergo biotransformation to form etritinate. Although Soriatane is completely cleared from the body after 36 days, patients treated with this drug should be checked for the possibility of the formation of etritinate, whose half-life of approximately 120 days.
Conditions Treated by Soriatane
Further applications of Soriatane are employed in severe keratinization disorders, like the Darier's disease (hereditary disease characterized by skin and mucous membrane changes). It is also used to treat lichen planus, fish scale disease (ichthyosis) and other skin diseases with excessive keratinization, such as hyperkeratosis. It also helps in the formation of healthy skin cells and reduces skin flaking to a large extent.
Soriatane Dosage Information
a.) Typical Dosage Recommendations
The dosage should be adjusted according to the body weight of the person. Soriatane is not well suited to aged patients.
Soriatane can cause serious birth defects in an unborn child, and therefore its use during pregnancy is strictly prohibited. General Soriatane should not be prescribed for women of childbearing age. In case a Soriatane medication cannot be avoided for certain medical reasons, the woman must be informed by the doctor thoroughly about the risks. You must use appropriate means of contraception. Pregnancy must be consistently avoided until two years after completion of therapy with Soriatane. Acitretin is excreted in breast milk. Therefore, lactating mothers should also not take the drug.
Soriatane usage has revealed numerous and severe side effects, most of which only adults can handle. Therefore the use of this substance in children should only be approved in unavoidable circumstances after a careful comparison of the benefits and risks by the treating physician.
b.) Missing A Dose
If you accidentally skip a Soriatane dose, take it as you soon as you remember. However, if it’s too late, move on to the next dose. Make sure you don’t miss out on multiple doses in quick succession.
If you experience nausea, vomiting, dizziness, lethargy, dizziness and blurred vision after a Soriatane dosage, immediately see a doctor or inform the emergency physician. These are some of the most common symptoms of an overdose. You may have to curtail the dosage (as per your doctor’s instruction) or absolutely stop the medication.
The contraceptive effect of estrogen-progestin combinations (birth-control pills) decreases. Contact lens wearers should wear glasses during therapy with the drug. Women of childbearing potential should not use Soriatane. They should not even receive blood from patients treated with the drug.
During treatment with the drug, you should not drink alcohol at all. Even in the first two months after the treatment is over, alcohol should be avoided at any cost.
Soriatane Side Effects
The extent and severity of adverse effects mainly depend on the dose of the drug. Especially at the beginning of treatment with Soriatane, a temporary worsening of psoriasis may occur. Common side effects.
The most common side effects of Soriatane include dry lips, formation of fissures, dry mouth, dryness of the nasal mucous membrane, inflammation of the nasal mucosa (rhinitis), nasal bleeding, dry skin, peeling of the skin, peeling of the skin on the palms, peeling of the skin on the sole, skin thinning, skin peeling, increased vulnerability of the skin, skin redness, itching, sensations in skin sensation, skin inflammation, skin discoloration, hair color changes, changes in hair growth rate, hair loss , inflammation of the nail wall, nail changes, conjunctivitis, visual impairment, ocular changes (xerophthalmia), thirst, chills and lipid disorders.
Uncommon side effects
Water retention (edema), flushing, blistering of the skin, and changes in hair texture, headache, muscle pain, joint pain, bone pain, fatigue, and increase in bilirubin. Bone changes in the course of long term treatment such as bone loss (osteoporosis), bone thinning, premature closure of bone growth plates, increased soft tissue calcification or ossification have also been reported.
Rare side effects
Corneal ulcers, corneal inflammation, stomach problems, intestinal problems like vomiting, abdominal pain, diarrhea, indigestion, liver inflammation (hepatitis) with skin yellowing (jaundice), increased light sensitivity of the skin, intracranial pressure (pseudotumor cerebri) with headache, dizziness, nausea, dizziness, blurred vision are extremely rare side effects.
Possible Drug Interactions With Soriatane
If Soriatane and phenytoin (Dilantin) (one of the AEDs) are taken together, the effect of phenytoin is strengthened. Simultaneous consumption of alcohol causes increased conversion of Soriatane to etretinate. This is also part of etretinate in the group of retinoids, and shows more side effects than Soriatane.
If a methotrexate (Trexall) drug is taken along with Soriatane, the risk of liver inflammation is increased. Tetracyclines (antibiotics) should not generally be co-administered with Soriatane. This may be accompanied by impairment of consciousness, difficulty in breathing and slow pulse. The contraceptive effect of low-dose estrogen-progestin combinations (birth control pill) can be reduced by Soriatane. The temporary choice of another means of contraception is therefore warranted.
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Notice: The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.