Quinine Sulfate and/or Equivalents
|Drug||Related Drug Names|
|Quinine Sulfate 200mg and/or Equivalents||Novo-Quinine, Quinine Sulfate, Quinine Sulphate|
|Quinine Sulfate 300mg and/or Equivalents||Quinine Sulfate, Quinine Sulphate, Teva-Quinine|
Quinine Sulfate Description
Quinine Sulfate or quinine has been used for treating the life threatening and serious disease malaria. Quinine Sulfate is a member of the medication class called as anti – malarials. Quinine occurs naturally and is obtained from a plant substance that is indigenous to South America. The native tribes have been known to using this drug for treating malaria several decades back. Eventually this medication has begun to be used across the world. However, only one product Qualaquin that is manufactured by Mutual Pharmaceutical Company has been approved by the FDA for treating malaria.
Quinine is extremely sensitive to UV or ultraviolet and in the presence of direct sun light, it will fluoresce because of its extremely conjugated resonance structure. Quinine can either be administered orally or intravenously although oral administration has been considered to be safe and effective. Quinine should be stored at 59o to 86o F and should be protected from moisture and direct light. Qualaquin capsules are available as stipulated by your physician.
Conditions Treated by Quinine
Besides the fact that quinine is used for treating malaria, the drug has also been used to prevent and treat leg muscle cramps that happen when your leg is at rest in the night. However, no quinine product has been approved by the FDA for treating nocturnal leg cramps. Quinine has also been used for treating arthritis and lupus. The medication has also been considered an effective muscle relaxant.
Quinune Dosage Information
a.) Typical Dosage Recommendations
648 mg of Qualaquin can be administered for every 8 hours for a period of seven days. Where patients suffer from severe chronic renal failure and acute uncomplicated malaria, 648 mg loading dose should be administered followed by maintenance doses of about 324 mg for every twelve hours. It is a recommended practice to administer this medication along with food in order to reduce GI upset. It is important for you to read through the medication guide before you self administer quinine. Dosage in children is dependent upon their weight. Taking less or more of this drug can result in serious implications.
b.) Missing A Dose
When you miss a dose or stop medication earlier than the period stipulated, you could end up making the infection a lot more difficult to treat or a relapse of the infection can also set in.
Overdosing can cause the following symptoms: adult respiratory distress syndrome, visual impairment, ventricular arrhythmias, pulmonary edema, hypotension, hypoglycemia, CNS toxicity, cinchonism, cardiotoxicity, cardiogenic shock, exacerbation of myocardial depression etc. Overdosing of quinine can be extremely toxic. Seeking the advice of a poisons specialist immediately is important. Erectile dysfunction of diarrhea and constipation can also occur.
Quinine contains certain inactive ingredients that can trigger an allergic reaction in you. The drug can cause dizziness or blurred vision. Therefore, it is advised not to use machinery or drive and do any kind of activities that involve clear vision and alertness. Alcoholic beverages should be limited. Quinine has a possibility of affecting your heart rhythm causing fainting and severe dizziness. This medication is not recommended for pregnant and lactating mothers. However, certain nursing infants are not affected by this drug. Testing your infant for a specific enzyme deficiency before breastfeeding is recommended. Injecting quinine accidentally into a nerve can result in paralysis. Patients with atrial fibrillation and conduction defects should avoid using quinine since abnormal heart rhythms can occur. Optic neuritis, myasthenia gravis and hemoglobinuria may worsen with the use of quinine.
Quinine Side Effects
Consult your healthcare provider immediately if you have experience one of the following allergic reactions: swelling of throat, tongue, lips or face. Any of the following adverse effects calls for immediate attention: purple spots under your skin, unusual weakness of muscles, yellow or pale colored skin and dark urine, weakness, confusion and fever, fainting or dizziness and weak pulse, uneven heart rhythm, breathing problems, chest pain, loss of appetite, fluttering and pounding heartbeats, stomach pain and diarrhea. Less serious effects include mild nausea, increased sweating, warmth and redness etc. In general, cardiovascular disorders, CNS, dermatalogic, genitourinary, hepatic, hypersenstivity, musculoskeletal and respiratory disorders are potential issues.
Possible Drug Interactions With Quinine
When quinine interacts with one or more of the following drugs, it can cause serious repercussions. Antacids that contain magnesium or aluminum can cause decreased or delayed absorption of quinine. Oral anticoagulants can result in depression of hepatic enzyme system. With Zantac (ranitidine) and Tagamet (cimetidine), quinine’s CI can reduce. Few other drugs that cause problems when consumed along with quinine include CYP1A2 substrates, Lanoxin(Digoxin) , erythromycin 500mg, Nizoral 400mg (ketoconazole), Lariam (mefloquine) , Neuromuscular blocking agents, Urinary alkalinizers, QT prolonging drugs, Dilantin (phenytoin), Rifadin (rifampin), Phenobarbital, CYP2D6, Tegretol (carbamazepine) etc.
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Notice: The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.