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 ----Not avalible in Canada----
PLEASE NOTE:
Zephrex is only available by prescription and REQUIRES A VALID PRESCRIPTION be sent to CanadaDrugs.com to complete your order.
* All prices are subject to change at any time. . For questions regarding pricing and availability of products from CanadaDrugs.comTM you may call 1-800-226-3784.
The following monograph is provided by Thomson Healthcare and may be related to the prescription drugs listed above. Drug monograph for the active ingredient in ZephrexThe following information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.
COUGH/COLD COMBINATIONS (Systemic)
Some commonly used brand names are:
In the U.S.—
- Alka-Seltzer Plus Cold and Cough 21
- Alka-Seltzer Plus Cold and Cough Medicine Liqui-Gels 34
- Alka-Seltzer Plus Night-Time Cold Liqui-Gels 35
- Ami-Tex LA 69
- Anatuss LA 70
- Benylin Expectorant 54
- Bromfed-DM 17
- Broncholate 68
- Carbinoxamine Compound-Drops 18
- Cardec DM 18
- Children's Tylenol Cold Plus Cough Multi Symptom 34
- Co-Apap 34
- Codeprex 1
- Comtrex Daytime Maximum Strength Cold, Cough, and
Flu Relief 60
- Comtrex Daytime Maximum Strength Cold and Flu Relief 60
- Comtrex Multi-Symptom Maximum Strength Non-Drowsy
Caplets 60
- Comtrex Nighttime Maximum Strength Cold and Flu Relief 34
- Congestac Caplets 70
- Contac Cold/Flu Day Caplets 60
- Contac Severe Cold and Flu Caplets 34
- Co-Tuss V 56
- Deconsal II 70
- Despec 69
- Despec-SR Caplets 70
- Donatussin 42
- Donatussin DC 62
- Duratuss 70
- Duratuss HD 65
- ED-TLC 22
- ED Tuss HC 22
- Endagen-HD 22
- Endal Expectorant 61
- Entex LA 69
- Father John's Medicine Plus 43
- Genatuss DM 54
- GP-500 70
- Guaifed 70
- Guaifenex PSE 60 70
- Guaifenex PSE 120 70
- GuaiMAX-D 70
- Guai-Vent/PSE 70
- Guiatuss A.C. 53
- Guiatuss CF 64
- Guiatuss DAC 63
- Guiatuss PE 70
- Histinex HC 22
- Histinex PV 25
- Hycodan 51
- Hycomine Compound 32
- Hydropane 51
- Iobid DM 54
- Iodal HD 22
- Iosal II 70
- Iotussin HC 22
- Kolephrin/DM Cough and Cold Medication 34
- Kolephrin GG/DM 54
- Kwelcof Liquid 56
- Mapap Cold Formula 34
- Marcof Expectorant 57
- Nalex DH 58
- Novahistine DH Liquid 23
- Nucofed Expectorant 63
- Nucofed Pediatric Expectorant 63
- Nucotuss Expectorant 63
- Nucotuss Pediatric Expectorant 63
- Nytcold Medicine 35
- Nytime Cold Medicine Liquid 35
- Ornex Severe Cold No Drowsiness Caplets 60
- PanMist-JR 70
- PediaCare Cough-Cold 24
- PediaCare Night Rest Cough-Cold Liquid 24
- Pediacof Cough 41
- Phanatuss 54
- Phenameth VC 14
- Phenergan with Codeine 5
- Phenergan with Dextromethorphan 6
- Phenergan VC with Codeine 29
- Pneumotussin HC 56
- Poly-Histine 15
- Primatuss Cough Mixture 4 2
- Primatuss Cough Mixture 4D 64
- Profen II 70
- Promethazine DM 6
- Promethazine VC w/Codeine 29
- Prometh VC with Codeine 29
- Protuss-D 66
- Pseudo-Car DM 18
- P-V-Tussin 26
- Quelidrine Cough 39
- Rentamine Pediatric 20
- Rescon-DM 24
- Rescon-GG 69
- Respa-1st 70
- Respa-DM 54
- Respaire-60 SR 70
- Respaire-120 SR 70
- Rhinosyn-DM 24
- Rhinosyn-DMX Expectorant 54
- Rhinosyn-X 64
- Robafen AC Cough 53
- Robafen DAC 63
- Robafen DM 54
- Robitussin A-C 53
- Robitussin Cold and Cough Liqui-Gels 64
- Robitussin Cold, Cough and Flu Liqui-Gels 67
- Robitussin-DAC 63
- Robitussin-DM 54
- Robitussin Night Relief 36
- Robitussin Night-Time Cold Formula 35
- Robitussin-PE 70
- Robitussin Pediatric Cough and Cold 59
- Robitussin Severe Congestion Liqui-Gels 70
- Rondamine-DM Drops 18
- Rondec-DM 18
- Rondec-DM Drops 18
- Ru-Tuss DE 70
- Ru-Tuss Expectorant 64
- Ryna-C Liquid 23
- Ryna-CX Liquid 63
- Rynatuss 20
- Rynatuss Pediatric 20
- Safe Tussin 30 54
- Scot-Tussin DM 2
- Scot-Tussin Senior Clear 54
- Sildec-DM 17
- Silexin Cough 54
- Siltussin DM 54
- Sinufed Timecelles 70
- Sinutab Non-Drying No Drowsiness Liquid Caps 70
- Stamoist E 70
- Statuss Green 19
- S-T Forte 2 3
- Sudafed Children's Non-Drowsy Cold and Cough 64
- Sudafed Cold and Cough Liquid Caps 67
- Sudafed Children's Cold and Cough 64
- Sudal 60/500 70
- Syracol CF 54
- TheraFlu Flu, Cold and Cough Medicine 34
- TheraFlu Maximum Strength Non-Drowsy Formula Flu,
Cold and Cough Medicine 60
- TheraFlu Maximum Strength Non-Drowsy Formula Flu,
Cold and Cough Medicine Caplets 60
- TheraFlu Nighttime Maximum Strength Flu, Cold and
Cough 34
- Tolu-Sed DM 54
- Touro DM 54
- Touro LA Caplets 70
- Triacin C Cough 30
- Triafed w/Codeine 30
- Triaminic AM Non-Drowsy Cough and Decongestant 59
- Triaminic Night Time 24
- Triaminic Sore Throat Formula 60
- Tri-Tannate Plus Pediatric 20
- Tussafed 18
- Tussafed Drops 18
- Tussar DM 21
- Tussigon 51
- Tussionex Pennkinetic 3
- Tussi-Organidin DM NR Liquid 54
- Tussi-Organidin DM-S NR Liquid 54
- Tussi-Organidin NR Liquid 53
- Tussi-Organidin-S NR Liquid 53
- Tussirex 47
- Tuss-LA 70
- Tusso-DM 55
- Tylenol Cold and Flu No Drowsiness Powder 60
- Tylenol Cold Medication 34
- Tylenol Cold Medication Caplets 34
- Tylenol Cold Medication, Non-Drowsy Caplets 60
- Tylenol Cold Medication, Non-Drowsy Gelcaps 60
- Tylenol Cold Multi-Symptom 34
- Tylenol Maximum Strength Flu Gelcaps 60
- Tylenol Multi-Symptom Cough 60
- Uni-tussin DM 54
- Vanex-HD 22
- V-Dec-M 70
- Versacaps 70
- Vicks Children's NyQuil Cold/Cough Relief 24
- Vicks 44 Cough and Cold Relief Non-Drowsy LiquiCaps 59
- Vicks 44D Cough and Head Congestion 59
- Vicks DayQuil Multi-Symptom Cold/Flu LiquiCaps 60
- Vicks DayQuil Multi-Symptom Cold/Flu Relief 60
- Vicks 44E Cough and Chest Congestion 54
- Vicks 44M Cough, Cold and Flu Relief 34
- Vicks NyQuil Hot Therapy 35
- Vicks NyQuil Multi-Symptom Cold/Flu LiquiCaps 35
- Vicks NyQuil Multi-Symptom Cold/Flu Relief 35
- Vicks Pediatric 44D Cough and Head Decongestion 59
- Vicks Children's Cough Syrup 54
- Vicks Pediatric 44M Multi-Symptom Cough and Cold 24
- Vicodin Tuss 56
- Zephrex 70
- Zephrex-LA 70
In Canada—
- Benylin DM-D 59
- Benylin DM-D for Children 59
- Benylin DM-D-E 64
- Benylin DM-D-E Extra Strength 64
- Benylin DM-E 54
- Benylin DM-E Extra Strength 54
- Benylin 4 Flu 67
- Calmydone 27
- Calmylin #2 59
- Calmylin #3 64
- Calmylin #4 10
- Calmylin Cough and Flu 67
- Calmylin DM-D-E Extra Strength 64
- Calmylin Original with Codeine 9
- Calmylin Pediatric 59
- Cheracol 52
- CoActifed 30
- CoActifed Expectorant 46
- Coristex-DH 58
- Coristine-DH 58
- Cotridin 30
- Cotridin Expectorant 46
- Dimetane Expectorant-C 37
- Dimetane Expectorant-DC 38
- Dimetapp-C 16
- Entex LA 69
- Histenol 60
- Hycodan 51
- Hycomine 45
- Mersyndol with Codeine 8
- NeoCitran DM Coughs and Colds 28
- Novahistex DH 58
- Novahistex DH Expectorant 62
- Novahistine DH 58
- Novahistine DM w/ Decongestant 59
- Novahistine DM Expectorant w/ Decongestant 64
- Penntuss 1
- Pharmasave Children's Cough Syrup 59
- Phenergan Expectorant w/ Codeine 13
- Robitussin A-C 11
- Robitussin with Codeine 11
- Robitussin Cough and Cold 64
- Robitussin Cough and Cold Liqui-Fills 64
- Robitussin-DM 54
- Robitussin-PE 70
- Robitussin Pediatric Cough and Cold 59
- Sinutab with Codeine 33
- Sudafed Cold and Flu Gelcaps 67
- Sudafed Cough and Cold Extra Strength Caplets 60
- Sudafed DM 59
- Tanta Cough Syrup 54
- Triaminic-DM Expectorant 44
- Triaminic DM NightTime for Children 24
- Tussilyn DM 24
- Tussionex 4
- Tylenol Children's Cold DM Medication 34
- Tylenol Cold and Flu 34
- Tylenol Cold Medication Extra Strength Daytime Caplets 60
- Tylenol Cold Medication Extra Strength Nighttime Caplets 34
- Tylenol Cold Medication Regular Strength Daytime Caplets 60
- Tylenol Cold Medication Regular Strength Nighttime
Caplets 34
- Tylenol Cough Extra Strength Caplets 50
- Tylenol Cough Medication with Decongestant, Regular
Strength 60
- Tylenol Cough Medication Regular Strength 50
- Tylenol Extra Strength Cold and Flu Medication Powder 34
- Tylenol Junior Strength Cold DM Medication 34
- Vicks Children's NyQuil 24
- Vicks DayQuil Liquicaps 60
- Vicks Formula 44-D 59
- Vicks Formula 44-D Pediatric 59
- Vicks Formula 44E 54
- Vicks Formula 44E Pediatric 54
- Vicks Formula 44M 34
- Vicks NyQuil 35
- Vicks NyQuil LiquiCaps 35
|
Note:
|
For quick reference the following cough/cold combinations are numbered
to match the preceding corresponding brand names. |
|
Note:
|
Products containing phenylpropanolamine were removed from the U.S.
and Canadian Markets in November 2000. |
| Antihistamine and antitussive combinations— |
| 1. |
Chlorpheniramine and Codeine (klor-fen-EER-a-meenand KOE-deen)† |
| 2. |
Chlorpheniramine and Dextromethorphan (klor-fen-EER-a-meen and dex-troe-meth-OR-fan)† |
| 3. |
Chlorpheniramine and Hydrocodone (klor-fen-EER-a-meen and hye-droe-KOE-done)† |
| 4. |
Phenyltoloxamine and Hydrocodone (fen-ill-tole-OX-a-meen and hye-droe-KOE-done)* |
| 5. |
Promethazine and Codeine (proe-METH-a-zeen and KOE-deen)†‡ |
| 6. |
Promethazineand Dextromethorphan (proe-METH-a-zeenand dex-troe-meth-OR-fan)† |
| 7. |
Pyrilamineand Codeine (peer-ILL-a-meen and KOE-deen)† |
| * Not commercially available in the U.S. |
| † Not commercially available in Canada |
| ‡ Generic name product may be available in the U.S. |
| Antihistamine, antitussive, and expectorant combinations— |
| 9. |
Diphenhydramine, Codeine, and Ammonium Chloride (dye-fen-HYE-dra-meen, KOE-deen, and a-MOE-nee-um KLOR-ide)* |
| 10. |
Diphenhydramine, Dextromethorphan, and Ammonium Chloride (dye-fen-HYE-dra-meen, dex-troe-meth-OR-fan, and a-MOE-nee-um KLOR-ide)* |
| 11. |
Pheniramine, Codeine, and Guaifenesin (fen-EER-a-meen, KOE-deen, and gwye-FEN-e-sin)* |
| 12. |
Pheniramine, Pyrilamine, Hydrocodone, Potassium Citrate, and Ascorbic Acid (fen-EER-a-meen, peer-ILL-a-meen,hye-droe-KOE-done, poe-TAS-ee-um SI-trate, and a-SKOR-bik AS-id)† |
| 13. |
Promethazine, Codeine, and Potassium Guaiacolsulfonate (proe-METH-a-zeen, KOE-deen, and poe-TAS-ee-um gwye-a-kol-SUL-fon-ate)* |
| * Not commercially available in the U.S. |
| † Not commercially available in Canada |
| Antihistamine, and decongestant combinations— |
| 14. |
Promethazine, and Phenylephrine ( proe-METH-a-zeen,and fen-ill-EF-rin )† |
| 15. |
Pheniramine, Pyrilamine and Phenyltoloxamine (fen-EER-a-meen, peer-ILL-a-meen, and fen-ill-tole-OX-a-meen)† |
| † Not commercially available in Canada |
| Antihistamine, decongestant, and antitussive combinations— |
| 16. |
Brompheniramine, Phenylephrine, and Codeine (brome-fen-EER-a-meen, fen-ill-EF-rin, and KOE-deen) |
| 17. |
Brompheniramine, Pseudoephedrine, and Dextromethorphan (brome-fen-EER-a-meen, soo-doe-e-FED-rin, and dex-troe-meth-OR-fan)† |
| 18. |
Carbinoxamine, Pseudoephedrine, and Dextromethorphan (kar-bi-NOX-a-meen, soo-doe-e-FED-rin, and dex-troe-meth-OR-fan)† |
| 19. |
Chlorpheniramine, Pyrilamine, Phenylephrine, Pseudoephedrine and Hydrocodone (klor-fen-EER-a-meen, peer-ILL-a-meen,fen-ill-EF-rin, soo-doe-e-FED-rin and hye-droe-KOE-done )† |
| 20. |
Chlorpheniramine, Ephedrine, Phenylephrine, and Carbetapentane (klor-fen-EER-a-meen, e-FED-rin, fen-ill-EF-rin, and kar-bay-ta-PEN-tane)† |
| 21. |
Chlorpheniramine, Phenylephrine, and Dextromethorphan (klor-fen-EER-a-meen, fen-ill-EF-rin, and dex-troe-meth-OR-fan)† |
| 22. |
Chlorpheniramine, Phenylephrine, and Hydrocodone (klor-fen-EER-a-meen, fen-ill-EF-rin, and hye-droe-KOE-done)† |
| 23. |
Chlorpheniramine, Pseudoephedrine, and Codeine (klor-fen-EER-a-meen, soo-doe-e-FED-rin, and KOE-deen)† |
| 24. |
Chlorpheniramine, Pseudoephedrine, and Dextromethorphan (klor-fen-EER-a-meen, soo-doe-e-FED-rin, and dex-troe-meth-OR-fan) |
| 25. |
Chlorpheniramine, Pseudoephedrine, and Hydrocodone (klor-fen-EER-a-meen, soo-doe-e-FED-rin, and hye-droe-KOE-done)† |
| 26. |
Chlorpheniramine, Pseudoephedrine, and Hydrocodone or Pseudoephedrine andHydrocodone (klor-fen-EER-a-meen,soo-doe-e-FED-rin, and hye-droe-KOE-done or soo-doe-e-FED-rin and hye-droe-KOE-done)† |
| 27. |
Doxylamine, Etafedrine, and Hydrocodone (dox-ILL-a-meen, et-a-FED-rin, and hye-droe-KOE-done)* |
| 28. |
Pheniramine, Phenylephrine, and Dextromethorphan (fen-EER-a-meen, fen-ill-EF-rin, and dex-troe-meth-OR-fan)* |
| 29. |
Promethazine, Phenylephrine, and Codeine (proe-METH-a-zeen, fen-ill-EF-rin, and KOE-deen)† |
| 30. |
Triprolidine, Pseudoephedrine, and Codeine (trye-PROE-li-deen, soo-doe-e-FED-rin, and KOE-deen) |
| * Not commercially available in the U.S. |
| † Not commercially available in Canada |
| Antihistamine, decongestant, antitussive, and analgesiccombinations— |
| 31. |
Chlorpheniramine, Pheniramine, Pyrilamine, Phenylephrine, Hydrocodone, Salicylamide,Caffeine, and Ascorbic Acid (klor-fen-EER-a-meen,fen-EER-a-meen, peer-ILL-a-meen, fen-ill-EF-rin, hye-droe-KOE-done, sal-i-SILL-a-mide,kaf-EEN, and a-SKOR-bik AS-id)† |
| 32. |
Chlorpheniramine,Phenylephrine, Hydrocodone, Acetaminophen, and Caffeine (klor-fen-EER-a-meen, fen-ill-EF-rin, hye-droe-KOE-done, a-seat-a-MIN-oh-fen,and kaf-EEN)† |
| 33. |
Chlorpheniramine, Pseudoephedrine, Codeine, and Acetaminophen (klor-fen-EER-a-meen, soo-doe-e-FED-rin,KOE-deen, and a-seat-a-MIN-oh-fen)* |
| 34. |
Chlorpheniramine,Pseudoephedrine, Dextromethorphan, and Acetaminophen (klor-fen-EER-a-meen, soo-doe-e-FED-rin, dex-troe-meth-OR-fan, and a-seat-a-MIN-oh-fen) |
| 35. |
Doxylamine, Pseudoephedrine, Dextromethorphan, andAcetaminophen (dox-ILL-a-meen, soo-doe-e-FED-rin,dex-troe-meth-OR-fan, and a-seat-a-MIN-oh-fen) |
| 36. |
Pyrilamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen (peer-ILL-a-meen, soo-doe-e-FED-rin, dex-troe-meth-OR-fan, and a-seat-a-MIN-oh-fen)† |
| * Not commercially available in the U.S. |
| † Not commercially available in Canada |
| Antihistamine, decongestant, antitussive, and expectorantcombinations— |
| 37. |
Brompheniramine, Phenylephrine, Codeine, and Guaifenesin (brome-fen-EER-a-meen, fen-ill-EF-rin, KOE-deen, and gwye-FEN-e-sin)* |
| 38. |
Brompheniramine, Phenylephrine, Hydrocodone, and Guaifenesin (brome-fen-EER-a-meen, fen-ill-EF-rin, hye-droe-KOE-done, and gwye-FEN-e-sin)* |
| 39. |
Chlorpheniramine, Ephedrine, Phenylephrine, Dextromethorphan,Ammonium Chloride, and Ipecac (klor-fen-EER-a-meen,e-FED-rin, fen-ill-EF-rin, dex-troe-meth-OR-fan, a-MOE-nee-um KLOR-ide, andIP-e-kak)† |
| 40. |
Chlorpheniramine, Phenylephrine, Codeine and AmmoniumChloride (klor-fen-EER-a-meen, fen-ill-EF-rin,KOE-deen, and a-MOE-nee-um KLOR-ide)† |
| 41. |
Chlorpheniramine,Phenylephrine, Codeine, and Potassium Iodide (klor-fen-EER-a-meen, fen-ill-EF-rin, KOE-deen, and por-TAS-ee-um EYE-oh-dyed)† |
| 42. |
Chlorpheniramine, Phenylephrine, Dextromethorphan,and Guaifenesin (klor-fen-EER-a-meen,fen-ill-EF-rin, dex-troe-meth-OR-fan, and gwye-FEN-e-sin)† |
| 43. |
Chlorpheniramine, Phenylephrine, Dextromethorphan, Guaifenesin, and AmmoniumChloride (klor-fen-EER-a-meen, fen-ill-EF-rin,dex-troe-meth-OR-fan, gwye-FEN-e-sin, and a-MOE-nee-um KLOR-ide)† |
| 44. |
Chlorpheniramine, Pseudoephedrine, Dextromethorphan, and Guaifenesin (klor-fen-EER-a-meen, soo-doe-e-FED-rin, dex-troe-meth-OR-fan, and gwye-FEN-e-sin)* |
| 45. |
Pyrilamine, Phenylephrine, Hydrocodone, and AmmoniumChloride (peer-ILL-a-meen, fen-ill-EF-rin,hye-droe-KOE-done, and a-MOE-nee-um KLOR-ide)* |
| 46. |
Triprolidine, Pseudoephedrine, Codeine, and Guaifenesin (trye-PROE-li-deen, soo-doe-e-FED-rin, KOE-deen, and gwye-FEN-e-sin)* |
| * Not commercially available in the U.S. |
| † Not commercially available in Canada |
| Antihistamine, decongestant, antitussive, expectorant,and analgesic combinations— |
| 47. |
Pheniramine, Phenylephrine, Codeine, Sodium Citrate, Sodium Salicylate, andCaffeine (fen-EER-a-meen, fen-ill-EF-rin,KOE-deen, SOE-dee-um SI-trate, SOE-dee-um sa-LI-sill-ate, and kaf-EEN)† |
| † Not commercially available in Canada |
| Antihistamine, decongestant, and expectorant combinations— |
| 48. |
Chlorpheniramine, Ephedrine, and Guaifenesin (klor-fen-EER-a-meen, e-FED-rin, and gwye-FEN-e-sin)† |
| 49. |
Promethazine, Phenylephrine, and Potassium Guaiacolsulfonate (pro-METH-a-zeen, fen-ill-EF-rin, and poe-TAS-see-um gwye-a-kol-SUL-fon-ate)* |
| * Not commercially available in the U.S. |
| † Not commercially available in Canada |
| Antitussive and analgesic combination— |
| 50. |
Dextromethorphan and Acetaminophen (dex-troe-meth-OR-fan and a-seat-a-MIN-oh-fen) |
| Antitussive and expectorant combinations— |
| 52. |
Codeine, Ammonium Chloride, and Guaifenesin (KOE-deen, a-MOE-nee-um KLOR-ide, and gwye-FEN-e-sin)* |
| 53. |
Codeine and Guaifenesin (KOE-deen and gwye-FEN-e-sin)†‡ |
| 54. |
Dextromethorphanand Guaifenesin (dex-troe-meth-OR-fanand gwye-FEN-e-sin) |
| 55. |
Dextromethorphan and Iodinated Glycerol (dex-troe-meth-OR-fan and EYE-oh-di-nay-ted GLI-ser-ole)† |
| 56. |
Hydrocodone and Guaifenesin (hye-droe-KOE-done and gwye-FEN-e-sin)†‡ |
| 57. |
Hydrocodoneand Potassium Guaiacolsulfonate (hye-droe-KOE-done and poe-TAS-see-um gwye-a-kol-SUL-fon-ate)† |
| * Not commercially available in the U.S. |
| † Not commercially available in Canada |
| ‡ Generic name product may be available in the U.S. |
| Decongestant and antitussive combinations— |
| 58. |
Phenylephrine and Hydrocodone (fen-ill-EF-rinand hye-droe-KOE-done) |
| 59. |
Pseudoephedrine and Dextromethorphan (soo-doe-e-FED-rin and dex-troe-meth-OR-fan) |
| Decongestant, antitussive, and analgesic combinations— |
| 60. |
Pseudoephedrine, Dextromethorphan, and Acetaminophen (soo-doe-e-FED-rin, dex-troe-meth-OR-fan, and a-seat-a-MIN-oh-fen) |
| Decongestant, antitussive, and expectorant combinations— |
| 61. |
Phenylephrine, Codeine, and Guaifenesin (fen-ill-EF-rin, KOE-deen, and gwye-FEN-e-sin)† |
| 62. |
Phenylephrine, Hydrocodone, and Guaifenesin (fen-ill-EF-rin, hye-droe-KOE-done, and gwye-FEN-e-sin) |
| 63. |
Pseudoephedrine, Codeine, and Guaifenesin (soo-doe-e-FED-rin, KOE-deen, and gwye-FEN-e-sin)‡ |
| 64. |
Pseudoephedrine, Dextromethorphan, and Guaifenesin (soo-doe-e-FED-rin, dex-troe-meth-OR-fan, and gwye-FEN-e-sin) |
| 65. |
Pseudoephedrine, Hydrocodone, and Guaifenesin (soo-doe-e-FED-rin, hye-droe-KOE-done, and gwye-FEN-e-sin)† |
| 66. |
Pseudoephedrine, Hydrocodone, and Potassium Guaiacolsulfonate (soo-doe-e-FED-rin, hye-droe-KOE-done, and poe-TAS-ee-um gwye-a-kol-SUL-fon-ate)† |
| † Not commercially available in Canada |
| ‡ Generic name product may be available in the U.S. |
| Decongestant, antitussive, expectorant, and analgesiccombinations— |
| 67. |
Pseudoephedrine, Dextromethorphan, Guaifenesin, and Acetaminophen (soo-doe-e-FED-rin, dex-troe-meth-OR-fan, gwye-FEN-e-sin, and a-seat-a-MIN-oh-fen) |
Category
- Antihistaminic (H 1
-receptor)-antitussive—Chlorpheniramine and Dextromethorphan; Chlorpheniramine and Hydrocodone; Phenyltoloxamine and Hydrocodone; Promethazine
and Codeine; Promethazine and Dextromethorphan; Pyrilamine and Codeine
- Antihistaminic (H 1
-receptor)-antitussive-analgesic—Doxylamine, Codeine and Acetaminophen
- Antihistaminic (H 1
-receptor)-antitussive-expectorant—Diphenhydramine, Codeine, and Ammonium Chloride; Diphenhydramine, Dextromethorphan, and
Ammonium Chloride; Pheniramine, Codeine,
and Guaifenesin; Pheniramine, Pyrilamine,
Hydrocodone, Potassium Citrate, and Ascorbic Acid; Promethazine, Codeine, and Potassium Guaiacolsulfonate
- Antihistaminic (H 1
-receptor)
and decongestant —Promethazine and Phenylephrine; Pheniramine, Pyrilamine, and Phenyltoloxamine
- Antihistaminic (H 1
-receptor)-decongestant-antitussive—Brompheniramine, Phenylephrine and Codeine; Brompheniramine, Pseudoephedrine, and Dextromethorphan; Carbinoxamine, Pseudoephedrine, and Dextromethorphan; Chlorpheniramine, Pyrilamine, Phenylephrine, Pseudoephedrine
and Hydrocodone; Chlorpheniramine, Ephedrine,
Phenylephrine, and Carbetapentane; Chlorpheniramine,
Phenylephrine, and Dextromethorphan; Chlorpheniramine,
Phenylephrine, and Hydrocodone; Chlorpheniramine,
Pseudoephedrine, and Codeine; Chlorpheniramine,
Pseudoephedrine, and Dextromethorphan; Chlorpheniramine, Pseudoephedrine, and Hydrocodone; Chlorpheniramine, Pseudoephedrine and Hydrocodone; Doxylamine, Etafedrine and Hydrocodone; Pheniramine, Phenylephrine, and Dextromethorphan; Promethazine, Phenylephrine, and Codeine; Triprolidine, Pseudoephedrine, and Codeine
- Antihistaminic (H 1
-receptor)-decongestant-antitussive-analgesic—Chlorpheniramine, Pheniramine, Pyrilamine,
Phenylephrine, Hydrocodone, Salicylamide, Caffeine, and Ascorbic Acid; Chlorpheniramine, Phenylephrine, Hydrocodone, Acetaminophen,
and Caffeine; Chlorpheniramine, Pseudoephedrine,
Codeine and Acetaminophen; Chlorpheniramine,
Pseudoephedrine, Dextromethorphan, and Acetaminophen, ; Doxylamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen; Pyrilamine, Pseudoephedrine, Dextromethorphan,
and Acetaminophen
- Antihistaminic (H 1
-receptor)-decongestant-antitussive-expectorant—Brompheniramine, Phenylephrine, Codeine and Guaifenesin; Brompheniramine, Phenylephrine, Hydrocodone
and Guaifenesin; Chlorpheniramine, Ephedrine,
Phenylephrine, Dextromethorphan, Ammonium Chloride, and Ipecac; Chlorpheniramine, Phenylephrine, Codeine, and Ammonium Chloride; Chlorpheniramine, Phenylephrine, Codeine,
and Potassium Iodide; Chlorpheniramine,
Phenylephrine, Dextromethorphan, and Guaifenesin; Chlorpheniramine, Phenylephrine, Dextromethorphan, Guaifenesin, and Ammonium
Chloride; Chlorpheniramine, Pseudoephedrine,
Dextromethorphan and Guaifenesin; Pyrilamine,
Phenylephrine, Hydrocodone, and Ammonium Chloride; Triprolidine, Pseudoephedrine, Codeine, and Guaifenesin
- Antihistaminic (H 1
-receptor)-decongestant-antitussive-expectorant-analgesic—Pheniramine, Phenylephrine, Codeine, Sodium
Citrate, Sodium Salicylate, and Caffeine
- Antihistaminic (H 1
-receptor)-decongestant-expectorant—Chlorpheniramine, Ephedrine, and Guaifenesin; Promethazine, Phenylephrine, and Potassium
Guaiacolsulfonate
- Antitussive-analgesic—Dextromethorphan and Acetaminophen
- Antitussive-anticholinergic—Hydrocodone and
Homatropine
- Antitussive-expectorant—Codeine, Ammonium Chloride, and Guaifenesin; Codeine and Guaifenesin; Dextromethorphan and Guaifenesin; Dextromethorphan
and Iodinated Glycerol; Hydrocodone and
Guaifenesin; Hydrocodone and Potassium
Guaiacolsulfonate
- Decongestant-antitussive—Phenylephrine and Hydrocodone; Pseudoephedrine and Dextromethorphan
- Decongestant-antitussive-analgesic—Pseudoephedrine, Dextromethorphan, and Acetaminophen
- Decongestant-antitussive-expectorant—Phenylephrine,
Codeine and Guaifenesin; Phenylephrine,
Hydrocodone, and Guaifenesin; Pseudoephedrine,
Codeine, and Guaifenesin; Pseudoephedrine,
Dextromethorphan, and Guaifenesin; Pseudoephedrine,
Hydrocodone, and Guaiacolsulfonate; Pseudoephedrine,
Hydrocodone, and Guaifenesin
- Decongestant-antitussive-expectorant-analgesic—Pseudoephedrine, Dextromethorphan, Guaifenesin,
and Acetaminophen
- Decongestant-expectorant—Ephedrine and Guaifenesin; Ephedrine and Potassium Iodide; Phenylephrine and Guaifenesin; Pseudoephedrine
and Guaifenesin
Description
Cough/cold combinations are used mainly to relieve the cough
due to colds, influenza, or hay fever. They are not to be used for the chronic
cough that occurs with smoking, asthma, or emphysema or when there is an unusually
large amount of mucus or phlegm (pronounced flem) with the cough.
Cough/cold combination products contain more than one ingredient. For example,
some products may contain an antihistamine, a decongestant, and an analgesic,
in addition to a medicine for coughing. If you are treating yourself, it is
important to select a product that is best for your symptoms. Also, in general,
it is best to buy a product that includes only those medicines you really
need. If you have questions about which product to buy, check with your pharmacist.
Since different products contain ingredients that will have different precautions
and side effects, it is important that you know the ingredients of the medicine
you are taking. The different kinds of ingredients that may be found in cough/cold
combinations include:
— Antihistamines—Antihistamines are used to relieve or prevent the symptoms of hay fever
and other types of allergy. They also help relieve some symptoms of the common
cold, such as sneezing and runny nose. They work by preventing the effects
of a substance called histamine, which is produced by the body. Some examples
of antihistamines contained in these combinations are: bromodiphenhydramine
(broe-moe-dye-fen-HYE-dra-meen),
brompheniramine (brome-fen-EER-a-meen), carbinoxamine (kar-bi-NOX-a-meen), chlorpheniramine (klor-fen-EER-a-meen), dexchlorpheniramine
(dex-klor-fen-EER-a-meen),
diphenhydramine (dye-fen-HYE-dra-meen), doxylamine (dox-ILL-a-meen), phenindamine (fen-IN-da-meen), pheniramine (fen-EER-a-meen), phenyltoloxamine (fen-ill-tole-OX-a-meen), pyrilamine (peer-ILL-a-meen), promethazine (proe-METH-a-zeen), and triprolidine (trye-PROE-li-deen).
— Decongestants—Decongestants, such as ephedrine (e-FED-rin), phenylephrine (fen-ill-EF-rin), and pseudoephedrine (soo-doe-e-FED-rin), produce a narrowing
of blood vessels. This leads to clearing of nasal congestion. However, this
effect may also increase blood pressure in patients who have high blood pressure.
— Antitussives—To help relieve coughing these combinations contain either a narcotic
[codeine (KOE-deen), dihydrocodeine (dye-hye-droe-KOE-deen), hydrocodone (hye-droe-KOE-done) or hydromorphone (hye-droe-MOR-fone)] or a nonnarcotic [carbetapentane (kar-bay-ta-PEN-tane), caramiphen (kar-AM-i-fen), or dextromethorphan (dex-troe-meth-OR-fan)] antitussive. These antitussives act directly on the
cough center in the brain. Narcotics may become habit-forming, causing mental
or physical dependence, if used for a long time. Physical dependence may
lead to withdrawal side effects when you stop taking the medicine.
— Expectorants—Guaifenesin (gwye-FEN-e-sin)
works by loosening the mucus or phlegm in the lungs. Other ingredients added
as expectorants (for example, ammonium chloride, calcium iodide, iodinated
glycerol, ipecac, potassium guaiacolsulfonate, potassium iodide, and sodium
citrate) have not been proven to be effective. In general, the best thing
you can do to loosen mucus or phlegm is to drink plenty of water.
— Analgesics—Analgesics, such as acetaminophen (a-seat-a-MIN-oh-fen), aspirin, and other salicylates [such
as salicylamide (sal-i-SILL-a-mide)
and sodium salicylate (SOE-dee-um sa-LI-sill-ate)] are used in these combination medicines to help relieve
the aches and pain that may occur with the common cold.
The use of too much acetaminophen and salicylates at the same time may
cause kidney damage or cancer of the kidney or urinary bladder. This may occur
if large amounts of both medicines are taken together for a long time. However,
taking the recommended amounts of combination medicines that contain both
acetaminophen and a salicylate for short periods of time has not been shown
to cause these unwanted effects.
— Anticholinergics—Anticholinergics such as homatropine (hoe-MA-troe-peen) may help produce a drying effect in the
nose and chest.
Some of these combinations are available only with your doctor's prescription.
Others are available without a prescription; however, your health care professional
may have special instructions on the proper dose of the medicine for your
medical condition.
Cough/cold combinations are available in the following dosage forms:
-
Antihistamine and antitussive combinations—
Oral
-
Chlorpheniramine and Codeine
-
Chlorpheniramine and Dextromethorphan
-
Chlorpheniramine and Hydrocodone
-
Oral solution (U.S.)
-
Oral suspension (U.S.)
-
Phenyltoloxamine and Hydrocodone
-
Oral suspension (Canada)
-
Tablets (Canada)
-
Promethazine and Codeine
-
Oral solution (U.S.)
-
Syrup (U.S.)
-
Promethazine and Dextromethorphan
-
Oral solution (U.S.)
-
Syrup (U.S.)
-
Pyrilamine and Codeine
-
Antihistamine, antitussive, and analgesic combinations—
Oral
-
Doxylamine, Codeine, and Acetaminophen
-
Antihistamine, antitussive, and expectorant combinations—
Oral
-
Diphenhydramine, Codeine, and Ammonium Chloride
-
Diphenhydramine, Dextromethorphan, and Ammonium Chloride
-
Pheniramine, Codeine, and Guaifenesin
-
Pheniramine, Pyrilamine, Hydrocodone, Potassium Citrate, and Ascorbic
Acid
-
Promethazine, Codeine, and Potassium Guaiacolsulfonate
-
Antihistamine, and decongestant combinations—
Oral
-
Promethazine, and phenylephrine
-
Pheniramine, Pyrilamine and Phenyltoloxamine
-
Antihistamine, decongestant, and antitussive combinations—
Oral
-
Bromopheniramine, Phenylephrine, and Codeine
-
Brompheniramine, Pseudoephedrine, and Dextromethorphan
-
Carbinoxamine, Pseudoephedrine, and Dextromethorphan
-
Oral solution (U.S.)
-
Syrup (U.S.)
-
Chlorpheniramine, Pyrilamine, Phenylephrine, Pseudoephedrine, and
Hydrocodone
-
Chlorpheniramine, Ephedrine, Phenylephrine, and Carbetapentane
-
Oral suspension (U.S.)
-
Tablets (U.S.)
-
Chlorpheniramine, Phenylephrine, and Dextromethorphan
-
Oral solution (U.S.)
-
Syrup (U.S.)
-
Tablets (U.S.)
-
Chlorpheniramine, Phenylephrine, and Hydrocodone
-
Oral solution (U.S.)
-
Syrup (U.S.)
-
Chlorpheniramine, Pseudoephedrine, and Codeine
-
Elixir (U.S.)
-
Oral solution (U.S.)
-
Chlorpheniramine, Pseudoephedrine, and Dextromethorphan
-
Chewable tablets (U.S.)
-
Oral solution (U.S. and Canada)
-
Syrup (U.S. and Canada)
-
Chlorpheniramine, Pseudoephedrine, and Hydrocodone
-
Oral solution (U.S.)
-
Syrup (U.S.)
-
Chlorpheniramine, Pseudoephedrine, and Hydrocodone
-
Doxylamine, Etadefrine, and Hydrocodone
-
Pheniramine, Phenylephrine, and Dextromethorphan
-
Promethazine, Phenylephrine, and Codeine
-
Oral solution (U.S.)
-
Syrup (U.S.)
-
Triprolidine, Pseudoephedrine, and Codeine
-
Oral solution (Canada)
-
Syrup (U.S.)
-
Tablets (Canada)
-
Antihistamine, decongestant, antitussive, and analgesic
combinations—
Oral
-
Chlorpheniramine, Pheniramine, Pyrilamine, Phenylephrine, Hydrocodone,
Salicylamide, Caffeine, and Ascorbic Acid
-
Chlorpheniramine, Phenylephrine, Hydrocodone, Acetaminophen, and
Caffeine
-
Chlorpheniramine, Pseudoephedrine, Codeine, and Acetaminophen
-
Chlorpheniramine, Pseudoephedrine, Dextromethorphan, and Acetaminophen
-
Capsules (U.S.)
-
Chewable tablets (U.S. and Canada)
-
Oral solution (U.S. and Canada)
-
Syrup (Canada)
-
Tablets (U.S. and Canada)
-
Doxylamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen
-
Capsules (U.S.)
-
Oral solution (U.S.)
-
Pyrilamine, Pseudoephedrine, Dextromethorphan, and Acetaminophen
-
Antihistamine, decongestant, antitussive, and expectorant
combinations—
Oral
-
Brompheniramine, Phenylephrine, Codeine, and Guaifenesin
-
Brompheniramine, Phenylephrine, Hydrocodone, and Guaifenesin
-
Chlorpheniramine, Ephedrine, Phenylephrine, Dextromethorphan, Ammonium
Chloride, and Ipecac
-
Chlorpheniramine, Phenylephrine, Codeine, and Ammonium Chloride
-
Chlorpheniramine, Phenylephrine, Codeine, and Potassium Iodide
-
Chlorpheniramine, Phenylephrine, Dextromethorphan, and Guaifenesin
-
Chlorpheniramine, Phenylephrine, Dextromethorphan, Guaifenesin, and
Ammonium Chloride
-
Chlorpheniramine, Pseudoephedrine, Dextromethorphan and Guaifenesin
-
Pyrilamine, Phenylephrine, Hydrocodone, and Ammonium Chloride
-
Triprolidine, Pseudoephedrine, Codeine, and Guaifenesin
-
Antihistamine, decongestant, antitussive, expectorant,
and analgesic combinations—
Oral
-
Pheniramine, Phenylephrine, Codeine, Sodium Citrate, Sodium Salicylate,
and Caffeine
-
Antihistamine, decongestant, and expectorant combinations—
Oral
-
Chlorpheniramine, Ephedrine, and Guaifenesin
-
Promethazine, Phenylephrine, and Potassium Guaiacolsulfonate
-
Antitussive and analgesic combination—
Oral
-
Dextromethorphan and Acetaminophen
-
Capsules (U.S.)
-
Oral solution (U.S.)
-
Oral suspension (Canada)
-
Tablets (U.S.)
-
Antitussive and anticholinergic combination—
Oral
-
Hydrocodone and Homatropine (Canadian product does not contain homatropine)
-
Syrup (U.S. and Canada)
-
Tablets (U.S. and Canada)
-
Antitussive and expectorant combinations—
Oral
-
Codeine, Ammonium Chloride, and Guaifenesin
-
Codeine and Guaifenesin
-
Oral solution (U.S.)
-
Syrup (U.S.)
-
Tablets (U.S.)
-
Dextromethorphan and Guaifenesin
-
Capsules (U.S.)
-
Extended-release capsules (U.S.)
-
Oral solution (U.S.)
-
Syrup (U.S. and Canada)
-
Tablets (U.S.)
-
Extended-release tablets (U.S.)
-
Dextromethorphan and Iodinated Glycerol
-
Hydrocodone and Guaifenesin
-
Oral solution (U.S.)
-
Syrup (U.S.)
-
Tablets (U.S.)
-
Hydrocodone and Potassium Guaiacolsulfonate
-
Oral solution (U.S.)
-
Syrup (U.S.)
-
Decongestant and antitussive combinations—
Oral
-
Phenylephrine and Hydrocodone
-
Oral solution (Canada)
-
Syrup (Canada)
-
Pseudoephedrine and Dextromethorphan
-
Capsules (U.S.)
-
Oral solution (U.S. and Canada)
-
Syrup (Canada)
-
Decongestant, antitussive, and analgesic combinations—
Oral
-
Pseudoephedrine, Dextromethorphan, and Acetaminophen
-
Capsules (U.S.)
-
Oral solution (U.S.)
-
Oral suspension (Canada)
-
Tablets (U.S. and Canada)
-
Decongestant, antitussive, and expectorant combinations—
Oral
-
Phenylephrine, Hydrocodone, and Guaifenesin
-
Phenylephrine, Hydrocodone, and Guaifenesin
-
Oral solution (Canada)
-
Syrup (U.S.)
-
Pseudoephedrine, Codeine, and Guaifenesin
-
Oral solution (U.S. and Canada)
-
Syrup (U.S. and Canada)
-
Pseudoephedrine, Dextromethorphan, and Guaifenesin
-
Capsules (U.S. and Canada)
-
Oral solution (U.S. and Canada)
-
Syrup (U.S. and Canada)
-
Tablets (U.S.)
-
Pseudoephedrine, Hydrocodone, and Guaifenesin
-
Elixir (U.S.)
-
Oral solution (U.S.)
-
Syrup (U.S.)
-
Tablets (U.S.)
-
Pseudoephedrine, Hydrocodone, and Potassium Guaiacolsulfonate
-
Decongestant, antitussive, expectorant, and analgesic
combinations—
Oral
-
Pseudoephedrine, Dextromethorphan, Guaifenesin, and Acetaminophen
-
Capsules (U.S.)
-
Oral solution (U.S. and Canada)
-
Syrup (Canada)
-
Tablets (U.S.)
-
Decongestant and expectorant combinations—
Oral
-
Ephedrine and Guaifenesin
-
Phenylephrine and Guaifenesin
-
Oral solution (U.S.)
-
Extended-release capsules (U.S.)
-
Extended-release tablets (U.S.)
-
Pseudoephedrine and Guaifenesin
-
Capsules (U.S.)
-
Extended-release capsules (U.S.)
-
Oral solution (U.S. and Canada)
-
Syrup (U.S. and Canada)
-
Tablets (U.S.)
-
Extended-release tablets (U.S.)
Before Using This Medicine
If you are taking this medicine
without a prescription, carefully read and follow any precautions on the label.
For cough/cold combinations, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual
or allergic reaction to any of the ingredients contained in this medicine.
Also tell your health care professional if you are allergic to any other substances,
such as foods, preservatives, or dyes. In addition, if this medicine contains
aspirin or other salicylates
, before taking it,
check with your doctor if you have ever had any unusual or allergic reaction
to any of the following medicines:
-
Aspirin or other salicylates
-
Diclofenac (e.g., Voltaren)
-
Diflunisal (e.g., Dolobid)
-
Fenoprofen (e.g., Nalfon)
-
Floctafenine
-
Flurbiprofen, by mouth (e.g., Ansaid)
-
Ibuprofen (e.g., Motrin)
-
Indomethacin (e.g., Indocin)
-
Ketoprofen (e.g., Orudis)
-
Ketorolac (e.g., Toradol)
-
Meclofenamate (e.g., Meclomen)
-
Mefenamic acid (e.g., Ponstel)
-
Methyl salicylate (oil of wintergreen)
-
Naproxen (e.g., Naprosyn)
-
Oxyphenbutazone (e.g., Tandearil)
-
Phenylbutazone (e.g., Butazolidin)
-
Piroxicam (e.g., Feldene)
-
Sulindac (e.g., Clinoril)
-
Suprofen (e.g., Suprol)
-
Tiaprofenic acid (e.g., Surgam)
-
Tolmetin (e.g., Tolectin)
-
Zomepirac (e.g., Zomax)
Diet—Make certain your health care professional
knows if you are on any special diet, such as a low-sodium or low-sugar diet.
Pregnancy—The occasional use of a cough/cold combination
is not likely to cause problems in the fetus or in the newborn baby. However,
when these medicines are used at higher doses and/or for a long time, the
chance that problems might occur may increase. For the individual ingredients
of these combinations, the following information should be considered before
you decide to use a particular cough/cold combination:
-
Acetaminophen
—Studies on birth defects
have not been done in humans. However, acetaminophen has not been shown to
cause birth defects or other problems in humans.
-
Alcohol
—Some of these combination
medicines contain a large amount of alcohol. Too much use of alcohol during
pregnancy may cause birth defects.
-
Antihistamines
—Antihistamines have
not been shown to cause problems in humans.
-
Caffeine
—Studies in humans have
not shown that caffeine causes birth defects. However, studies in animals
have shown that caffeine causes birth defects when given in very large doses
(amounts equal to the amount of caffeine contained in 12 to 24 cups of coffee
a day).
-
Codeine
—Although studies on birth
defects with codeine have not been done in humans, it has not been reported
to cause birth defects in humans. Codeine has not been shown to cause birth
defects in animal studies, but it caused other unwanted effects. Also, regular
use of narcotics during pregnancy may cause the baby to become dependent on
the medicine. This may lead to withdrawal side effects after birth. In addition,
narcotics may cause breathing problems in the newborn baby if taken by the
mother just before delivery.
-
Hydrocodone
—Although studies on
birth defects with hydrocodone have not been done in humans, it has not been
reported to cause birth defects in humans. However, hydrocodone has been shown
to cause birth defects in animals when given in very large doses. Also, regular
use of narcotics during pregnancy may cause the baby to become dependent on
the medicine. This may lead to withdrawal side effects after birth. In addition,
narcotics may cause breathing problems in the newborn baby if taken by the
mother just before delivery.
-
Iodides (e.g., calcium iodide and iodinated glycerol)
—Not recommended during pregnancy. Iodides have caused enlargement
of the thyroid gland in the fetus and resulted in breathing problems in newborn
babies whose mothers took iodides in large doses for a long period of time.
-
Phenylephrine
—Studies on birth defects
with phenylephrine have not been done in either humans or animals.
-
Pseudoephedrine
—Studies on birth
defects with pseudoephedrine have not been done in humans. In animal studies
pseudoephedrine did not cause birth defects but did cause a decrease in average
weight, length, and rate of bone formation in the animal fetus when given
in high doses.
-
Salicylates (e.g., aspirin)
—Studies
on birth defects in humans have been done with aspirin, but not with salicylamide
or sodium salicylate. Salicylates have not been shown to cause birth defects
in humans. However, salicylates have been shown to cause birth defects in
animals.
Some reports have suggested that too much use of aspirin late in pregnancy
may cause a decrease in the newborn's weight and possible death of the fetus
or newborn infant. However, the mothers in these reports had been taking much
larger amounts of aspirin than are usually recommended. Studies of mothers
taking aspirin in the doses that are usually recommended did not show these
unwanted effects. However, there is a chance that regular use of salicylates
late in pregnancy may cause unwanted effects on the heart or blood flow in
the fetus or newborn baby.
Use of salicylates, especially aspirin, during the last 2 weeks of pregnancy
may cause bleeding problems in the fetus before or during delivery, or in
the newborn baby. Also, too much use of salicylates during the last 3 months
of pregnancy may increase the length of pregnancy, prolong labor, cause other
problems during delivery, or cause severe bleeding in the mother before, during,
or after delivery. Do not take aspirin during the last
3 months of pregnancy unless it has been ordered by your doctor
.
Breast-feeding—If you are breast-feeding, the chance that problems
might occur depends on the ingredients of the combination. For the individual
ingredients of these combinations, the following apply:
-
Acetaminophen
—Acetaminophen passes
into the breast milk. However, it has not been reported to cause problems
in nursing babies.
-
Alcohol
—Alcohol passes into the
breast milk. However, the amount of alcohol in recommended doses of this medicine
does not usually cause problems in nursing babies.
-
Antihistamines
—Small amounts of
antihistamines pass into the breast milk. Antihistamine-containing medicine
is not recommended for use while breast-feeding since most antihistamines
are especially likely to cause side effects, such as unusual excitement or
irritability, in the baby. Also, since antihistamines tend to decrease the
secretions of the body, the flow of breast milk may be reduced in some patients.
-
Caffeine
—Small amounts of caffeine
pass into the breast milk and may build up in the nursing baby. However, the
amount of caffeine in recommended doses of this medicine does not usually
cause problems in nursing babies.
-
Decongestants (e.g., ephedrine, phenylephrine,
, pseudoephedrine)
—Phenylephrine has not been reported to cause
problems in nursing babies. Ephedrine and pseudoephedrine pass into the breast
milk and may cause unwanted effects in nursing babies (especially newborn
and premature babies).
-
Iodides (e.g., calcium iodide and iodinated glycerol)
—These medicines pass into the breast milk and may cause unwanted
effects, such as underactive thyroid, in the baby.
-
Narcotic antitussives (e.g., codeine, dihydrocodeine,
hydrocodone, and hydromorphone)
—Small amounts of codeine have
been shown to pass into the breast milk. However, the amount of codeine or
other narcotic antitussives in recommended doses of this medicine has not
been reported to cause problems in nursing babies.
-
Salicylates (e.g., aspirin)
—Salicylates
pass into the breast milk. Although salicylates have not been reported to
cause problems in nursing babies, it is possible that problems may occur if
large amounts are taken regularly.
Children—Very young children are usually more sensitive
to the effects of this medicine. Before giving any of
these combination medicines to a child, check the package label very carefully.
Some of these medicines are too strong for use in children
. If you
are not certain whether a specific product can be given to a child, or if
you have any questions about the amount to give, check with your health care
professional, especially if it contains:
-
Antihistamines
—Nightmares, unusual
excitement, nervousness, restlessness, or irritability may be more likely
to occur in children taking antihistamines.
-
Decongestants (e.g., ephedrine, phenylephrine,
pseudoephedrine)
—Increases in blood pressure may be more likely
to occur in children taking decongestants.
-
Narcotic antitussives (e.g., codeine, hydrocodeine,
hydrocodone, and hydromorphone)
—Breathing problems may be especially
likely to occur in children younger than 2 years of age taking narcotic antitussives.
Also, unusual excitement or restlessness may be more likely to occur in children
receiving these medicines.
-
Salicylates (e.g., aspirin)
— Do not give medicines containing aspirin or other salicylates
to a child with a fever or other symptoms of a virus infection, especially
flu or chickenpox, without first discussing its use with your child's doctor
. This is very important because salicylates may cause a serious illness
called Reye's syndrome in children with fever caused by a virus infection,
especially flu or chickenpox. Also, children may be more sensitive to the
aspirin or other salicylates contained in some of these medicines, especially
if they have a fever or have lost large amounts of body fluid because of vomiting,
diarrhea, or sweating.
Adolescents—Do not give medicines containing
aspirin or other salicylates to a teenager with a fever or other symptoms
of a virus infection, especially flu or chickenpox, without first discussing
its use with your child's doctor
. This is very important because salicylates
may cause a serious illness called Reye's syndrome in teenagers with fever
caused by a virus infection, especially flu or chickenpox.
Older adults—The elderly are usually more sensitive to the effects
of this medicine, especially if it contains:
-
Antihistamines
—Confusion, difficult
or painful urination, dizziness, drowsiness, feeling faint, or dryness of
mouth, nose, or throat may be more likely to occur in elderly patients. Also,
nightmares or unusual excitement, nervousness, restlessness, or irritability
may be more likely to occur in the elderly taking antihistamines.
-
Decongestants (e.g., ephedrine, phenylephrine,
pseudoephedrine)
—Confusion, hallucinations, drowsiness, or convulsions
(seizures) may be more likely to occur in the elderly, who are usually more
sensitive to the effects of this medicine. Also, increases in blood pressure
may be more likely to occur in elderly persons taking decongestants.
Other medicines—Although certain medicines should not be used
together at all, in other cases two different medicines may be used together
even if an interaction might occur. In these cases, your doctor may want to
change the dose, or other precautions may be necessary. Tell your health care
professional if you are taking any
other prescription
or nonprescription (over-the-counter [OTC]) medicine, for example, aspirin
or other medicine for allergies. Some medicines may change the way this medicine
affects your body. Also, the effect of other medicines may be increased or
reduced by some of the ingredients in this medicine. Check with your health
care professional about which medicines you should not take with this medicine.
Other medical problems—The presence of other medical
problems may affect the use of the cough/cold combination medicine. Make sure
you tell your doctor if you have any other medical problems, especially:
-
Alcohol abuse (or history of)—Acetaminophen-containing medicines
increase the chance of liver damage; also, some of the liquid medicines contain
a large amount of alcohol
-
Anemia or
-
Gout or
-
Hemophilia or other bleeding problems or
-
Stomach ulcer or other stomach problems—These conditions may
become worse if you are taking a combination medicine containing aspirin or
another salicylate
-
Brain disease or injury or
-
Colitis or
-
Convulsions (seizures) (history of) or
-
Diarrhea or
-
Gallbladder disease or gallstones—These conditions may become
worse if you are taking a combination medicine containing codeine, dihydrocodeine,
hydrocodone, or hydromorphone
-
Cystic fibrosis (in children)—Side effects of iodinated glycerol
may be more likely in children with cystic fibrosis
-
Diabetes mellitus (sugar diabetes)—Decongestants may put diabetic
patients at greater risk of having heart or blood vessel disease
-
Emphysema, asthma, or chronic lung disease (especially in children)—Salicylate-containing
medicine may cause an allergic reaction in which breathing becomes difficult
-
Enlarged prostate or
-
Urinary tract blockage or difficult urination—Some of the effects
of anticholinergics (e.g., homatropine) or antihistamines may make urinary
problems worse
-
Glaucoma—A slight increase in inner eye pressure may occur
with the use of anticholinergics (e.g., homatropine) or antihistamines, which
may make the condition worse
-
Heart or blood vessel disease or
-
High blood pressure—Decongestant-containing medicine may increase
the blood pressure and speed up the heart rate; also, caffeine-containing
medicine, if taken in large amounts, may speed up the heart rate
-
Kidney disease—This condition may increase the chance of side
effects of this medicine because the medicine may build up in the body
-
Liver disease—Liver disease increases the chance of side effects
because the medicine may build up in the body; also, if liver disease is severe,
there is a greater chance that aspirin-containing medicine may cause bleeding
-
Thyroid disease—If an overactive thyroid has caused a fast
heart rate, the decongestant in this medicine may cause the heart rate to
speed up further; also, if the medicine contains narcotic antitussives (e.g.,
codeine), iodides (e.g., iodinated glycerol), or salicylates, the thyroid
problem may become worse
Proper Use of This Medicine
To help
loosen mucus or phlegm in the lungs, drink a glass of
water after each dose of this medicine
, unless otherwise directed by
your doctor.
Take this medicine only as directed
. Do not
take more of it and do not take it more often than recommended on the label,
unless otherwise directed by your doctor. To do so may increase the chance
of side effects.
For patients taking the extended-release capsule or
tablet form of this medicine
:
-
Swallow the capsule or tablet whole.
-
Do not crush, break, or chew before swallowing.
-
If the capsule is too large to swallow, you may mix the contents
of the capsule with applesauce, jelly, honey, or syrup and swallow without
chewing.
For patients taking the extended-release oral solution
or oral suspension form of this medicine
:
-
Do not dilute with fluids or mix with other drugs.
For patients taking a combination medicine containing
an antihistamine and/or aspirin or other salicylate
:
-
Take with food or a glass of water or milk to lessen stomach irritation,
if necessary.
If a combination medicine containing aspirin has a
strong vinegar-like odor, do not use it
. This odor means the medicine
is breaking down. If you have any questions about this, check with your pharmacist.
Missed dose—If you must take this medicine regularly and
you miss a dose, take it as soon as possible. However, if it is almost time
for your next dose, skip the missed dose and go back to your regular dosing
schedule. Do not double doses.
Storage—To store this medicine:
-
Keep this medicine out of the reach of children. Overdose is very
dangerous in young children.
-
Store away from heat and direct light.
-
Do not store the capsule or tablet form of this medicine in the bathroom,
near the kitchen sink, or in other damp places. Heat or moisture may cause
the medicine to break down.
-
Keep the liquid form of this medicine from freezing. Do not refrigerate
the syrup.
-
Do not keep outdated medicine or medicine no longer needed. Be sure
that any discarded medicine is out of the reach of children.
Precautions While Using This Medicine
If your
cough has not improved after 7 days or if you have a high fever, skin rash,
continuing headache, or sore throat with the cough, check with your doctor.
These signs may mean that you have other medical problems.
For patients taking antihistamine-containing medicine
:
-
Before you have any skin tests for allergies, tell the doctor in
charge that you are taking this medicine. The results of the test may be affected
by the antihistamine in this medicine.
-
This medicine will add to the effects of alcohol and other CNS depressants
(medicines that slow down the nervous system, possibly causing drowsiness).
Some examples of CNS depressants are antihistamines or medicine for hay fever,
other allergies, or colds; sedatives, tranquilizers, or sleeping medicine;
prescription pain medicine or narcotics; barbiturates; medicine for seizures;
muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while
you are taking this medicine
.
-
This medicine may cause some people to become drowsy, dizzy, or less
alert than they are normally. Make sure you know how
you react to this medicine before you drive, use machines, or do anything
else that could be dangerous if you are dizzy or are not alert
.
-
When taking antihistamines on a regular basis, make sure your doctor
knows if you are taking large amounts of aspirin at the same time (as in arthritis
or rheumatism). Effects of too much aspirin, such as ringing in the ears,
may be covered up by the antihistamine.
-
Antihistamines may cause dryness of the mouth. For temporary relief,
use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva
substitute. However, if your mouth continues to feel dry for more than 2 weeks,
check with your medical doctor or dentist. Continuing dryness of the mouth
may increase the chance of dental disease, including tooth decay, gum disease,
and fungus infections.
For patients taking decongestant-containing medicine
:
-
This medicine may add to the central nervous system (CNS) stimulant
effects of diet aids. Do not use medicines for diet
or appetite control while taking this medicine unless you have checked with
your doctor
.
-
This medicine may cause some people to be nervous or restless or
to have trouble in sleeping. If you have trouble in sleeping, take the last dose of this medicine for each day a few hours before bedtime
. If you have any questions about this, check with your doctor.
-
Before having any kind of surgery (including dental surgery) or emergency
treatment, tell the medical doctor or dentist in charge that you are taking
this medicine.
For patients taking narcotic antitussive (codeine,
dihydrocodeine, hydrocodone, or hydromorphone)-containing medicine
:
-
This medicine will add to the effects of alcohol and other CNS depressants
(medicines that slow down the nervous system, possibly causing drowsiness).
Some examples of CNS depressants are antihistamines or medicine for hay fever,
other allergies, or colds; sedatives, tranquilizers, or sleeping medicine;
prescription pain medicine or narcotics; barbiturates; medicine for seizures;
muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while
you are taking this medicine
.
-
This medicine may cause some people to become drowsy, dizzy, less
alert than they are normally, or to feel a false sense of well-being. Make sure you know how you react to this medicine before you
drive, use machines, or do anything else that could be dangerous if you are
dizzy or are not alert and clearheaded
.
-
Nausea or vomiting may occur after taking a narcotic antitussive.
This effect may go away if you lie down for a while. However, if nausea or
vomiting continues, check with your doctor.
-
Dizziness, lightheadedness, or fainting may be especially likely
to occur when you get up suddenly from a lying or sitting position. Getting
up slowly may help lessen this problem.
-
Before having any kind of surgery (including dental surgery) or emergency
treatment, tell the medical doctor or dentist in charge that you are taking
this medicine.
For patients taking iodide (calcium iodide, iodinated
glycerol, or potassium iodide)-containing medicine
:
-
Make sure your doctor knows if you are planning to have any future
thyroid tests. The results of the thyroid test may be affected by the iodine
in this medicine.
For patients taking analgesic-containing medicine
:
-
Check the label of all nonprescription (over-the-counter
[OTC]), and prescription medicines you now take
. If any contain acetaminophen
or aspirin or other salicylates, including diflunisal or bismuth subsalicylate,
be especially careful. Taking them while taking a cough/cold combination medicine
that already contains them may lead to overdose. If you have any questions
about this, check with your health care professional.
-
Do not take aspirin-containing medicine for 5 days before any surgery,
including dental surgery, unless otherwise directed by your medical doctor
or dentist. Taking aspirin during this time may cause bleeding problems.
For diabetic patients taking aspirin- or sodium salicylate-containing
medicine
:
-
False urine sugar test results may occur:
-
If you take 8 or more 325-mg (5-grain) doses of aspirin every day
for several days in a row.
-
If you take 8 or more 325-mg (5-grain), or 4 or more 500-mg (10-grain)
doses of sodium salicylate.
-
Smaller doses or occasional use of aspirin or sodium salicylate usually
will not affect urine sugar tests. If you have any questions about this, check
with your health care professional, especially if your diabetes is not well
controlled.
For patients taking homatropine-containing medicine
:
-
This medicine may make you sweat less, causing your body temperature
to increase. Use extra care not to become overheated
during exercise or hot weather while you are taking this medicine
,
since overheating may result in heat stroke. Also, hot baths or saunas may
make you feel dizzy or faint while you are taking this medicine.
Side Effects of This Medicine
Along with its needed effects, a medicine
may cause some unwanted effects. Although serious side effects occur rarely
when this medicine is taken as recommended, they may be more likely to occur
if:
-
too much medicine is taken.
-
it is taken in large doses.
-
it is taken for a long period of time.
Get emergency help immediately
if any of the following symptoms of overdose occur
:
For narcotic antitussive (codeine, dihydrocodeine, hydrocodone, or hydromorphone)-containing
Cold, clammy skin; confusion (severe); convulsions (seizures); drowsiness or dizziness (severe); nervousness or
restlessness (severe); pinpoint pupils of eyes; slow heartbeat; slow or troubled breathing; weakness (severe)
For acetaminophen-containing
Diarrhea; increased sweating; loss of appetite; nausea or vomiting; stomach cramps or pain; swelling or tenderness in the upper abdomen or stomach area
For salicylate-containing
Any loss of hearing; bloody urine; confusion; convulsions (seizures); diarrhea (severe or continuing); dizziness
or lightheadedness; drowsiness (severe); excitement or nervousness (severe); fast or deep breathing; fever; hallucinations (seeing, hearing, or feeling things that are not there); increased sweating; nausea or vomiting
(severe or continuing); shortness of breath or troubled
breathing (for salicylamide only); stomach pain (severe
or continuing); uncontrollable flapping movements
of the hands, especially in elderly patients; unusual
thirst; vision problems
For decongestant-containing
Fast, pounding, or irregular heartbeat; headache (continuing and severe); nausea or vomiting
(severe); nervousness or restlessness (severe); shortness of breath or troubled breathing (severe or continuing)
Also, check with your doctor as soon as possible if any of the following
side effects occur:
For antihistamine- or anticholinergic-containing
Clumsiness or unsteadiness; convulsions
(seizures); drowsiness (severe); dryness of mouth, nose, or throat (severe); flushing
or redness of face; hallucinations (seeing, hearing,
or feeling things that are not there); restlessness
(severe); shortness of breath or troubled breathing; slow or fast heartbeat
For iodine-containing
Headache (continuing); increased watering
of mouth; loss of appetite; metallic taste; skin rash, hives, or redness; sore throat; swelling of face, lips,
or eyelids
For acetaminophen-containing
Other side effects may occur that usually do not need medical
attention. These side effects may go away during treatment as your body adjusts
to the medicine. However, check with your doctor if any of the following side
effects continue or are bothersome:
Constipation; decreased sweating; difficult or painful urination; dizziness
or lightheadedness; drowsiness; dryness of mouth, nose, or throat; false sense of
well-being; increased sensitivity of skin to sun; nausea or vomiting; nightmares; stomach pain; thickening
of mucus; trouble in sleeping; unusual excitement, nervousness, restlessness, or irritability; unusual tiredness or weakness Not all of the
side effects listed above have been reported for each of these medicines,
but they have been reported for at least one of them. There are some similarities
among these combination medicines, so many of the above side effects may occur
with any of these medicines.
Other side effects not listed above may also occur in
some patients. If you notice any other effects, check with your doctor.
Revised: 10/27/2004
The information contained in the Thomson Healthcare products is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse or pharmacist can provide you with advice on what is safe and effective for you. The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Healthcare makes no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products. Copyright © 2004 Thomson Healthcare Inc. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.
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